What is ADP-ribosylation factor like 4C?

ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins . ARL4C is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in cholesterol transport.

What is the function of the ADP-ribosylation factor 1?

The ADP-Ribosylation Factor 1 acts as a master regulator of Golgi structure and function through the recruitment and activation of various downstream effectors .

What are the effects of ADP-ribosylation?

ADP-ribosylation is the addition of one or more ADP-ribose moieties to a protein. It is a reversible post-translational modification that is involved in many cellular processes, including cell signaling, DNA repair, gene regulation and apoptosis . Improper ADP-ribosylation has been implicated in some forms of cancer.

What toxin causes ADP-ribosylation of EF2?

Diphtheria toxin inactivates protein synthesis elon- gation factor 2 by catalyzing the ADP-ribosylation of a novel derivative of histidine, diphthamide, in the pro- tein (Van Ness, B. G., Howard, J. B., and Bodley, J.

What is the role of ADP in the body?

Adenosine diphosphate (ADP) is a biological molecule consisting of one adenine, one sugar, and two phosphates. Its most important role is that it is combined with a phosphate molecule to make ATP, the premier energy molecule in living cells . ADP is also used to help activate platelets in clotting.

How does ADP work in the body?

ADP is stored in dense bodies inside blood platelets and is released upon platelet activation. ADP interacts with a family of ADP receptors found on platelets (P2Y1, P2Y12, and P2X1), which leads to platelet activation . P2Y1 receptors initiate platelet aggregation and shape change as a result of interactions with ADP.

What is the meaning of ribosylation?

ADP-ribosylation is the post-translational modification of proteins through the transfer of ADP-ribose from NAD + to a specific amino acid within a substrate . 1 . Substrates can be modified with a single ADP-ribose moiety (mono-ADP ribosylation) or poly-ADP ribose (PAR) chains.

What is the adenosine ribosylation factor?

Adenosine diphosphate-ribosylation factor (Arf) proteins are members of the Arf arm of the Ras superfamily of guanosine triphosphate (GTP)-binding proteins . Arfs are named for their activity as cofactors for cholera toxin-catalyzed adenosine diphosphate-ribosylation of the heterotrimeric G protein Gs.

What is ADP-ribosylation factor like protein 1?

Data show that ADP-ribosylation factor-related protein 1 (ARFRP1) is associated mainly with the trans-Golgi compartment and the trans-Golgi network (TGN) and is an essential regulatory factor for targeting of golgin-97 and golgin-245 onto Golgi membranes .

What is an example of ADP-ribosylation?

For example, Mono-ADP-ribosylation on H4 seems to occur preferentially when H4 is hyperacetylated and mono-ADP-ribosylation of histone H1. 3 on arginine 33 (R33) may reduce cyclic AMP-dependent phosphorylation of Serine 36 (S36) [67].

What is ADP-ribosylation of elongation factor 2?

Elongation factor 2 (EF2) Following ADP-ribosylation, EF2 is unable to carry out protein synthesis, and this causes rapid cell death . The region containing diphthamide 715 is very close to the anticodon recognition domain of EF2. This suggests that ADP-ribosylation interferes with EF2 binding to the tRNA.

Arl4c ADP-ribosylation factor-like 4C [Mus musculus (house mouse)]

Summary

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Official Symbol: Arl4cprovided by MGI
Official Full Name: ADP-ribosylation factor-like 4Cprovided by MGI
Primary source: MGI:MGI:2445172
See related: Ensembl:ENSMUSG00000049866 AllianceGenome:MGI:2445172
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LAK; Arl7; A630084M22Rik
Summary: Predicted to enable GTP binding activity and alpha-tubulin binding activity. Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to be located in cytosol. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; dorsal root ganglion; retina; and trigeminal nerve. Orthologous to human ARL4C (ADP ribosylation factor like GTPase 4C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

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See Arl4c in Genome Data Viewer

Location:: 1 D; 1 44.85 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (88625947..88629913, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (88698225..88702191, complement)

Chromosome 1 - NC_000067.7

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arl4c is involved in tooth germ development through osteoblastic/ameloblastic differentiation.
Title: Arl4c is involved in tooth germ development through osteoblastic/ameloblastic differentiation.
CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis.
Title: CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis.
describe that miR-26, an LXR-suppressed miRNA, inhibits the expression of the ATP-binding cassette transporter A1 (ABCA1) and ADP-ribosylation factor-like 7 (ARL7), two LXR target genes which play critical roles in cholesterol efflux
Title: MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7.
an important role of LXRs in the coordinated regulation of lipid metabolic and inflammatory gene programs in macrophages
Title: Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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hom*ology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 4C

Names: ADP-ribosylation factor-like 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177305.4 → NP_796279.2 ADP-ribosylation factor-like protein 4C

See identical proteins and their annotated locations for NP_796279.2

Status: VALIDATED

Source sequence(s)

AC115303, BC055769, BU709624

Consensus CDS

CCDS15146.1

UniProtKB/Swiss-Prot

P61208

UniProtKB/TrEMBL

Q8BV33

Related

ENSMUSP00000124344.2, ENSMUST00000159814.2

Conserved Domains (1) summary

cd04152
Location:11 → 192

Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases