Summary
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- Official Symbol
- Arl4cprovided by MGI
- Official Full Name
- ADP-ribosylation factor-like 4Cprovided by MGI
- Primary source
- MGI:MGI:2445172
- See related
- Ensembl:ENSMUSG00000049866 AllianceGenome:MGI:2445172
- Gene type
- protein coding
- RefSeq status
- VALIDATED
- Organism
- Mus musculus
- Lineage
- Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
- Also known as
- LAK; Arl7; A630084M22Rik
- Summary
- Predicted to enable GTP binding activity and alpha-tubulin binding activity. Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to be located in cytosol. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; dorsal root ganglion; retina; and trigeminal nerve. Orthologous to human ARL4C (ADP ribosylation factor like GTPase 4C). [provided by Alliance of Genome Resources, Apr 2022]
- Orthologs
- human all
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Genomic context
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See Arl4c in Genome Data Viewer
- Location:
- 1 D; 1 44.85 cM
- Exon count:
- 1
Annotation release | Status | Assembly | Chr | Location |
---|---|---|---|---|
RS_2024_02 | current | GRCm39 (GCF_000001635.27) | 1 | NC_000067.7 (88625947..88629913, complement) |
108.20200622 | previous assembly | GRCm38.p6 (GCF_000001635.26) | 1 | NC_000067.6 (88698225..88702191, complement) |
Chromosome 1 - NC_000067.7
Genomic regions, transcripts, and products
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Go to reference sequence details
Go to nucleotide: Graphics FASTA GenBank
Bibliography
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Related articles in PubMed
- A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures. Matsumoto S, et al. EMBO J, 2014 Apr 1. PMID 24562386, Free PMC Article
- Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. Hong C, et al. J Lipid Res, 2011 Mar. PMID 21187453, Free PMC Article
- ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal. Jacobs S, et al. FEBS Lett, 1999 Aug 13. PMID 10462049
- MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7. Sun D, et al. FEBS Lett, 2012 May 21. PMID 22673513
- CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis. Han JS, et al. Proc Natl Acad Sci U S A, 2020 Sep 15. PMID 32873638, Free PMC Article
See all (22) citations in PubMed
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
- Arl4c is involved in tooth germ development through osteoblastic/ameloblastic differentiation.
Title: Arl4c is involved in tooth germ development through osteoblastic/ameloblastic differentiation.
- CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis.
Title: CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis.
- describe that miR-26, an LXR-suppressed miRNA, inhibits the expression of the ATP-binding cassette transporter A1 (ABCA1) and ADP-ribosylation factor-like 7 (ARL7), two LXR target genes which play critical roles in cholesterol efflux
Title: MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7.
- an important role of LXRs in the coordinated regulation of lipid metabolic and inflammatory gene programs in macrophages
Title: Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target.
Submit: New GeneRIF Correction
Variation
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Interactions
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Products | Interactant | Other Gene | Complex | Source | Pubs | Description |
---|
General gene information
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hom*ology
- NCBI Orthologs Orthologs from OrthoDB
Gene Ontology Provided by MGI
Function | Evidence Code | Pubs |
---|---|---|
enables GTP binding | IBA Inferred from Biological aspect of Ancestor | |
enables GTPase activity | IEA Inferred from Electronic Annotation | |
enables alpha-tubulin binding | ISO Inferred from Sequence Orthology | |
enables nucleotide binding | IEA Inferred from Electronic Annotation |
Process | Evidence Code | Pubs |
---|---|---|
involved_in endocytic recycling | IBA Inferred from Biological aspect of Ancestor | |
involved_in endocytic recycling | ISO Inferred from Sequence Orthology | |
involved_in intracellular protein transport | IBA Inferred from Biological aspect of Ancestor |
Component | Evidence Code | Pubs |
---|---|---|
located_in cell projection | IEA Inferred from Electronic Annotation | |
is_active_in cytoplasm | IBA Inferred from Biological aspect of Ancestor | |
located_in cytoplasm | ISO Inferred from Sequence Orthology | |
located_in cytosol | ISO Inferred from Sequence Orthology | |
located_in membrane | IEA Inferred from Electronic Annotation | |
is_active_in plasma membrane | IBA Inferred from Biological aspect of Ancestor | |
located_in plasma membrane | ISO Inferred from Sequence Orthology |
General protein information
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- Preferred Names
- ADP-ribosylation factor-like protein 4C
- Names
- ADP-ribosylation factor-like 7
NCBI Reference Sequences (RefSeq)
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RefSeqs maintained independently of Annotated Genomes
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
-
NM_177305.4 → NP_796279.2 ADP-ribosylation factor-like protein 4C
See identical proteins and their annotated locations for NP_796279.2
Status: VALIDATED
- Source sequence(s)
- AC115303, BC055769, BU709624
- Consensus CDS
- CCDS15146.1
- UniProtKB/Swiss-Prot
- P61208
- UniProtKB/TrEMBL
- Q8BV33
- Related
- ENSMUSP00000124344.2, ENSMUST00000159814.2
- Conserved Domains (1) summary
-
- cd04152
Location:11 → 192 - Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
- cd04152
RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02
The following sections contain reference sequences that belong to a specific genome build. Explain
Reference GRCm39 C57BL/6J
Genomic
-
NC_000067.7Reference GRCm39 C57BL/6J
- Range
- 88625947..88629913 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
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Nucleotide | Protein | Strain | |
---|---|---|---|
Heading | Accession and Version |
Protein Accession | Links | |
---|---|---|
GenPept Link | UniProtKB Link | |
P61208.1 | GenPept | UniProtKB/Swiss-Prot:P61208 |
Additional links
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Gene LinkOut
The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.
- Interologous Interaction Database
- MilliporeSigma
- Bgee database
- BioGPS
- BioGRID Open Repository of CRISPR Screens (ORCS)
- CREB Target Gene Database
- CTD: Comparative Toxicogenomics Database
- Eukaryotic Promoter Database
- GlyGen glycoinformatics resource
- Ingenuity Pathways Analysis
- InnateDB
- Kyoto Encyclopedia of Genes and Genomes
- OMA Browser: Orthologous MAtrix
- OrthoDB catalog of orthologs
- PANTHER Classification System
- PhosphoSitePlus
- Addgene Non-profit plasmid repository
- ExactAntigen/Labome
- GenScript latest version of gene cDNA ORF Clone
- GeneCopoeia Inc.
- OriGene